Click Here to return To Results

 

Association of Apolipoprotein E Polymorphism with Outcome after Head Injury Lancet 350:1069-1071, Teasdale,G.M.,et al, 1997 See this aricle in Pubmed Article Abstract Variation in outcome after head injury is not fully explained by known prognostic features.Polymorphism of the apolipoprotein E gene(APOE) influences neuropathological findings in patients who die from head injuries.Detailed information on outcome was available for 89 patients. Seventeen(57%)of 30 patients with APOE E4 had an unfavorable outcome(dead, vegetative state or severe disability)compared with 16(27%)of the 59 patients without APOE(p=0.006).The association remained significant when adjustment was made to control for age,GCS and computed tomography scan findings(p=0.024).Our findings show a significant genetic association of APOE polymorphism with outcome after head injury supporting the hypothesis of a genetically determined influence.Patients with APOE E4 are more than twice as likely as those without APOE E4 to have an unfavorable outcome six months after head injury.Further,studies are underway to confirm and further evaluate this association.

Related Tags

(click to filter results - removes previous filter) apolipoprotein E head injury head injury,prognosis in prognosis

Click Here to return To Results